NEET PG Pathology MCQs 173 – Liver, Gall bladder, Pancreas Disorders – 6

1.Wilson’s disease is characterized by

  1. Increased serum ceruloplasmin
  2. Decreased copper excretion in urine
  3. Increased copper in the liver
  4. Autosomal dominant

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2. Diabetic patient with liver cirrhosis and hyperpigmentation, diagnosis is

  1. Wilson’s disease
  2. Hemochromatosis
  3. Primary sclerosing cholangitis
  4. Hepatitis B

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3. Type of inheritance in Wilson’s disease

  1. Autosomal dominant
  2. Autosomal recessive
  3. X-linked dominant
  4. X-linked recessive

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4. ATP7B gene is present on chromosome

  1. 5
  2. 13
  3. 18
  4. 21

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5. Gene for Wilson disease is

  1. ATP 7A
  2. ATP 7B
  3. ADP 7C
  4. ADP 7D

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6. The most common gene responsible for hereditary hemochromatosis is

  1. HN gene
  2. HAMP gene
  3. TtR2 gene
  4. HFE gene

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7. Which of the following histologic changes is most likely to be seen in a biopsy specimen taken from the liver of a pat who died from an overdose of acetaminophen

  1. Centrilobular necrosis
  2. Focal scattered necrosis
  3. Midzonal necrosis
  4. Periportal necrosis

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8. Intake of which of these cause vascular lesions in the liver

  1. Halothanes
  2. INH
  3. Steroids
  4. CPZ

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9. Centrilobular necrosis in the liver is due to all except

  1. Halothane
  2. Chronic venous congestion
  3. Yellow fever
  4. Hemorrhagic shock

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10. The most common site of cholangiocarcinoma is

  1. Distal biliary tree
  2. Hilum
  3. Intrahepatic biliary duct
  4. Multifocal

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11. Klatskin tumor is

  1. Nodular type of cholangiocarcinoma
  2. Fibrolamellar hepatocellular carcinoma
  3. Gall bladder carcinoma
  4. Hepatocellular carcinoma

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12. The commonest cause of the Budd-Chiari syndrome is

  1. Valves in the hepatic vein
  2. Hepatocellular carcinoma
  3. Thrombosis of hepatic veins
  4. Idiopathic

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13. Nutmeg liver is a feature of

  1. Viral hepatitis
  2. Cirrhosis
  3. Chronic venous congestion
  4. Alcoholic liver disease

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14. Vinyl chloride has been implicated in

  1. Angiosarcoma of liver
  2. Angiosarcoma of nose
  3. Hepatomas
  4. Bladder cancer

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15. Hepatocellular CA is most frequently associated with

  1. Mixed micronodular cirrhosis
  2. Alcoholic cirrhosis
  3. NANB virus
  4. Increase Cu++content

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16. Fibrolamellar carcinoma of the liver

  1. Occurs after 60 yrs of age
  2. Has better prognosis
  3. Diffuse in nature
  4. Cirrhosis is the most common presenting feature

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17. Cholangiocarcinoma true is

  1. Undifferentiated carcinoma usually
  2. Evokes abundant fibroblastic proliferation
  3. Bile present with tumor cells
  4. All of the above

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18. A young woman Ms. Shaano who is otherwise normal goes for an annual examination in a nursing home.Her blood investigations reveal hemoglobin is 15 g*/dl, TLC is 7,000/-mm3, ESR is L2mmlhr. Her kidney and liver radiological scanning too. Dr.sethi, The radiologist describes her findings to be normal except a mass in the right lobe of the liver. A biopsy is taken which confirms the diagnosis of a liver adenoma. Which of the following is likely to be associated with this lesion

  1. Polycythemia Vera
  2. Hepatitis B
  3. Oral contraceptives
  4. Polyvinyl chloride

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19. Commonest benign tumor of the liver is

  1. Hamartoma
  2. Hemangioma
  3. Adenoma
  4. Nodular focal hyperplasia

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20. Liver granulomas may be associated with all of the following except

  1. Candida
  2. Halothane
  3. Sarcoidosis
  4. Hepatic metastasis

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21. Which malignancy is associated with liver cirrhosis

  1. Hepatocellular Ca
  2. Cholangiocarcinoma
  3. Fibrolamellar Ca
  4. Pancreatic Ca

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22. Which is a risk factor for cholangiocarcinoma

  1. Persistent hepatitis
  2. Ulcerative colitis
  3. Crohn’s ds
  4. Chronic cholecystitis

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23. Thorium dioxide causes

  1. Lymphoma
  2. Lymphangiosarcoma
  3. Angiosarcoma
  4. Hemangioendothelioma

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24. Klatskin tumor is

  1. Nodular type of cholangiocarcinoma
  2. Fibrolamellar hepatocellular carcinoma
  3. Gall bladder carcinoma
  4. Hepatocellular carcinoma

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25. Nutmeg liver is seen in::

  1. Right-sided heart failure
  2. Left-sided heart failure
  3. Decreased pulmonary pressure
  4. Chronic hepatitis

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