NEET PG Pathology MCQs 176 – Liver, Gall bladder, Pancreas Disorders – 9

1.A child presented with viral fever followed by unconsciousness. CT scan was suggestive of cerebral edema. Which of the following would be a finding on liver biopsy?

  1. Piecemeal necrosis
  2. Microvesicular steatosis
  3. Bridging fibrosis
  4. Ballooning degeneration

Ans(2)

2. The pathological manifestation of chronic alcoholism includes all of the following except:

  1. Piecemeal necrosis
  2. Ballooning degeneration
  3. Microvesicular fatty changes
  4. Central hyaline sclerosis

Ans(1)

3. True about surgical jaundice

  1. Increase of serum bilirubin
  2. Increase acid phosphatase
  3. Increase alkaline phosphatase
  4. Urine bilirubin is absent
  5. Stool stercobilinogen absent

Ans (1)

4. Regarding Gilbert’s syndrome, which one of the following statements is not correct?

  1. Jaundice becomes severe with time
  2. Hyperbilirubinemia increases after fasting
  3. Inheritance of disease is autosomal dominant
  4. Liver histology is normal

Ans (2)

5. A 55-year-old gentleman presented with a history of right upper quadrant discomfort, jaundice, pruritis, fever, fatigue, and weight loss. His serum bilirubin and alkaline phosphatase levels are raised and he also gives a history of treatment for inflammatory bowel disease. He is most likely to be suffering from

  1. Benign bile duct stricture with cholangitis
  2. Biliary worms
  3. Bile duct malignancy
  4. Primary sclerosing cholangitis

Ans (4)

6. True about primary biliary cirrhosis

  1. More common in female
  2. Periportal fibrosis
  3. May be associated with Rheumatoid arthritis & Crohn’s disease
  4. Jaundice may be present
  5. Autoimmune disease is seen

Ans (12,4,5)

7. Florid duct lesions are diagnostic of

  1. Klatskin tumor
  2. Primary sclerosing cholangitis
  3. Primary biliary cirrhosis
  4. Secondary biliary cirrhosis

Ans (3)

8. False statement regarding Alagille syndrome

  1. Mutation in jagged-1 gene
  2. Portal and bile ducts are completely absent
  3. Micronodular cirrhosis of the liver
  4. All of the above

Ans (3)

9. Onion skin fibrosis is seen in

  1. Primary biliary cirrhosis
  2. Secondary biliary cirrhosis
  3. Primary sclerosing cholangitis
  4. Progressive familial intrahepatic cholestasis

Ans (3)

10. Which of the following does not cause cholestasis in newborn

  1. ABO incompatibility
  2. Sepsis
  3. Tyrosinemia
  4. Biliary atresia

Ans (1)

11. All of the following are autosomal recessive except

  1. Gilbert’s syndrome
  2. Crigler Najjar type I
  3. Crigler Najjar type II
  4. Dubin Johnson syndrome

Ans (3)

12. Antimitochondrial antibodies are positive in

  1. Primary sclerosing cholangitis
  2. Secondary biliary cirrhosis
  3. Primary biliary cirrhosis
  4. Primary hemochromatosis

Ans (3)

13. Which one of the following inherited conditions cause direct hyperbilirubinemia

  1. Gilbert syndrome
  2. Type I Crigler-Najjar syndrome
  3. Rotor syndrome
  4. Type II Crigler-Najjar syndrome

Ans (3)

14. About Gilbert syndrome, true are all except

  1. Causes cirrhosis
  2. Autosomal dominant
  3. Normal liver function test
  4. Normal histology

Ans (1)

15. Unconjugated hyperbilirubinemia is seen in

  1. Rotor syndrome
  2. Dubin-Johnson syndrome
  3. Gilbert syndrome
  4. Bile duct obstruction

Ans (3

16. Feature of unconjugated bilirubin is/are

  1. Water soluble
  2. Fat soluble
  3. Direct reaction with Van den Bergh reaction
  4. Affinity for brain tissue
  5. Increased in hemolytic anemia

Ans (2,4,5)

17. What is/are true about bilirubin?

  1. Conjugation is rate limited step
  2. Bilirubin has an affinity for elastin
  3. Conjugated bilirubin is maximum in blood
  4. Total Hb content of the body is 750 gm
  5. Unconjugated bilirubin is direct Van der Bergh positive

Ans (2,4)

18. Liver biopsy is normal in

  1. Dubinjohnson syndrome
  2. Gilbert syndrome
  3. Hemochromatosis
  4. Wilson disease
  5. Rotor’s syndrome

Ans (2,5)

19. Pigment stone is composed of?

  1. Ca bituminate
  2. Ca phosphate
  3. Ca carbonate
  4. Ca gluconate

Ans (1

20. Sclerosing cholangitis is associated with

  1. Ulcerative colitis
  2. Celiac sprue
  3. Wilson’s disease
  4. Whipple’s disease

Ans (1)

21. Conjugated hyperbilirubinemia is seen in?

  1. Dubin Johnson syndrome
  2. Gilbert syndrome
  3. Crigler Najjar Syndrome
  4. Hemolysis

Ans (1)

22. The grossly pigmented liver is seen in?

  1. Crigler-Najjar Type I
  2. Gilberts Syndrome
  3. Dubin Johnson syndrome
  4. Rotor’s syndrome

Ans (3)

23. The following features differentiate Rotor syndrome from Dubin Johnson’s syndrome Except

  1. Liver in patients with Rotor syndrome has no increased pigmentation and appears normal.
  2. In Rotor syndrome, Gall’s bladder is usually visualized on cholecystography
  3. Total urinary coproporphyrin is substantially increased in Rotor syndrome
  4. The fraction of coproporphyrin I in urine is elevated usually more than 80% of the total in Rotor syndrome

Ans (4)

24. Primary biliary cirrhosis is positive for

  1. ANCA
  2. Anti-mitochondrial antibody
  3. Anti-nuclear antibody
  4. Anti-microsomal antibody

Ans (2)

25. True about cholelithiasis is?

  1. Cholesterol stones are most common
  2. 90% of gallstone are radio-opaque
  3. Mirrizi syndrome is due to impaction of stone in Hartmann’s pouch
  4. Hemolytic anemia cause black colored stone
  5. Carcinoma is not a risk associated with gallstone

Ans (1,3,4)



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