NEET PG Pathology MCQs 177 – Liver, Gall bladder, Pancreas Disorders – 10

1. All are true about ascending cholangitis except

  1. Most commonly caused by gram-positive organisms
  2. In severe cases, collapse can occur
  3. Urgent removal of the stone by ERCP can be done
  4. Cholecystectomy can be done
  5. Commonly caused by obstruction of the bile duct by a stone

Ans (1)

2. True about Crigler-Najjar syndrome type II

  1. Autosomal dominant
  2. Kernicterus is frequently present
  3. The child may live to adolescence
  4. Cause unconjugated hyperbilirubinemia
  5. Phenobarbitone therapy is ineffective

Ans (1,3,4)

3. True about obstructive jaundice

  1. Unconjugated bilirubin
  2. Positive indirect Van den Bergh
  3. Pruritus
  4. Pale Stools
  5. Icterus

Ans (3,4,5)

4. In post-hepatic jaundice, the concentration of conjugated bilirubin in the blood is higher than that of unconjugated bilirubin because

    1. There is an increased rate of destruction of red blood cells
    2. The unconjugated bilirubin is trapped by the bile stone produced in the bile duct
    3. The unconjugated process of bilirubin in the liver remains operative without any interference
    4. The UDP-glucuronosyl transferase activity is increased manifold in obstructive jaundice

Ans (3)

5. Primary sclerosing cholangitis, true is?

    1. More common in females
    2. Associated with IBD
    3. Involves intra & extrahepatic ducts
    4. ERCP not helpful
    5. ANCA positive

Ans (2,3,5)

6. The Rh-ve woman became pregnant with Rh +ve fetus. Within a few days after birth, the infant developed jaundice, ascites, hepatomegaly, and edema. The likely substance(s) deposited in skin and sclera in jaundice is/are?

    1. Biliverdin
    2. Conjugated and unconjugated bilirubin
    3. Unconjugated bilirubin
    4. Conjugated bilirubin
    5. Hemochromatosis

Ans (2)

7. Conjugated hyperbilirubinemia is seen in

    1. Rotor’s syndrome
    2. Dubin Johnson syndrome
    3. Gilbert’s syndrome
    4. Breast milk jaundice
    5. Crigler-Najjar syndrome

Ans (1,2)

8. Histopathologic features of bile duct obstruction are

    1. The proliferation of bile duct
    2. Bile lakes
    3. Portal fibrosis
    4. Cholestasis
    5. Mallory hyaline body

Ans (1,2,3,4,5)

9. Intracanalicular hepatic apparatus is affected in?

    1. Alagille syndrome
    2. Cystic fibrosis
    3. Congenital hepatic fibrosis
    4. Caroli’s disease
    5. Polycystic liver disease

Ans (1,2,3,4,5)

10. Lipoprotein X is elevated in

    1. Primary biliary cirrhosis
    2. Indian childhood cirrhosis
    3. Hypercholesterolemia
    4. Alcoholic steatosis
    5. Hepatocellular Carcinoma

Ans (1)

11. A 1-month-old child with conjugated bilirubinemia and intrahepatic cholestasis. On Liver biopsy and staining with PAS red colored granules were seen inside the hepatocytes, probable diagnosis is?

  1. Alpha Antitrypsin deficiency
  2. Congenital hepatic fibrosis
  3. Wilson disease
  4. Hereditary hemochromatosis

Ans(1)

12. PAS-positive, diastase-resistant globules in hepatocytes are seen in:

  1. Hemochromatosis
  2. Wilsons disease
  3. Alpha 1 antitrypsin deficiency
  4. Acute necrotic hepatitis

Ans(3)

13. Hemochromatosis is a defect in the metabolism of:

  1. Iron
  2. Copper
  3. Magnesium C
  4. Calcium

Ans(1)

14. Gene for Wilson’s disease is located on chromosome:

  1. 7
  2. 10
  3. 13
  4. 17

Ans(3)

15. Wilson’s diocese is characterized by-

  1. Increased serum ceruloplasmin
  2. Decreased copper excretion in urine
  3. ↑ Ceruloplasmin
  4. Low ↑ Ceruloplasmin high urine copper

Ans(4)

16. Diabetic patient with liver cirrhosis and hyperpigmentation, diagnosis is:

  1. Wilson’s disease
  2. Hemochromatosis
  3. Primary sclerosing cholangitis
  4. Hepatitis B

Ans(2)

17. Type of inheritance in Wilson’s disease:

  1. Autosomal dominant
  2. Autosomal recessive
  3. X-linked dominant
  4. X-linked recessive

Ans(2)

18. PAS-positive intrahepatic globules are seen in:

  1. Wilson disease
  2. Hemochromatosis
  3. Primary Sclerosing Cholangitis
  4. Alpha-1 antitrypsin deficiency

Ans(4)

19. ATP7B gene is present on chromosome:

  1. 5
  2. 13
  3. 18
  4. 21

Ans(2)

20. In Alpha-1 antitrypsin deficiency, hepatocytes are:

  1. PAS + ve diastase resistant
  2. Diastase positive PAS resistant
  3. PAS –ve
  4. Oil red O positive

Ans(1)

21. Does hemochromatosis lead to deposition of?

  1. Iron
  2. Copper
  3. Zinc
  4. Lead

Ans(1)

22. In Wilson’s disease, hepatic copper content usually exceeds ______µg per gram dry weight:

  1. 150
  2. 250
  3. 350
  4. 450

Ans(2)

23. The most common gene responsible for hereditary hemochromatosis is?

  1. HJV gene
  2. HAMP gene
  3. TfR2 gene
  4. HFE gene

Ans(4)

24. Which of the following leads to chronic liver disease?

  1. Hepatitis A
  2. EBC
  3. Infectious mononucleosis
  4. α-1 antitrypsin deficiency

Ans(4)

25. Histological finding in Reye’s syndrome-

  1. Budding and branching of mitochondria
  2. Swelling of endoplasmic reticulum
  3. Paranuclearmicrodense deposits
  4. Glycogen depletion

Ans(4)


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