NEET PG Pathology MCQs 36 – Genetic Disorders – 12

  1. Mutation leads to sickle cell anemia
    1. Crossover mutation
    2. Frameshift
    3. Deletion
    4. Point mutation
      1. Ans(4)
  2. Angelman syndrome is due to
    1. Digenic inheritance
    2. Inversion
    3. Uniparental disomy
    4. Mitochondrial disorder
      1. Ans(3)
  3. All of the following are autosomal dominant disorders except:
    1. Gardener’s syndrome
    2. Ataxia -telangiectasia
    3. Neurofibromatosis
    4. Peutz-jeghers syndrome
      1. Ans(1)
  4. Which of the following procedures are the routine technique for karyotyping using light microscopy
    1. C-banding
    2. Q-banding
    3. G-banding
    4. Brd V-staining
      1. Ans(3)
  5. Which of the following is X-linked recessive:
    1. G6 PD deficiency
    2. Neurofibromatosis
    3. Thalassemia
    4. Alkaptonuria
      1. Ans(1)
  6. Down syndrome is most commonly caused by:
    1. Maternal nondisjunction
    2. Paternal dysfunction
    3. Translocation
    4. Mosaicism
      1. Ans(1)
  7. Gene instability associated with malignancy is seen in:
    1. Klippel -Fell syndrome
    2. Ataxia -telangiectasia
    3. Marfan’s syndrome
    4. EDS
      1. Ans(2)
  8. Gene involved in Rett syndrome
    1. P 53
    2. MECP 2
    3. RB
    4. BRCA
      1. Ans(2)
  9. Single gene disorder which does not follow Mendelian inheritance is:
    1. Sickle cell anemia
    2. Down syndrome
    3. Fragile X-syndrome
    4. Retinoblastoma
      1. Ans(3)
  10. Mitochondrial DNA is known for all except:
    1. Maternal inheritance
    2. Heteroplasmy
    3. Leber hereditary optic neuropathy is the prototype
    4. Nemaline myopathy results due to mutations in my -DNA
      1. Ans(4)
  11. True about genomic imprinting
    1. Differential expression of a gene depending on parent or origin
    2. Prader-Willi syndrome is a maternal deletion of chromosome 15
    3. Angelman syndrome is due to paternal deletion of chromosome 15
    4. Uniparental disomy is another name of genomic imprinting
      1. Ans(1)
  12. Superotemporal lental subluxation is seen in:
    1. Weill -Marcheasani syndrome
    2. Marfan’s syndrome
    3. Hunter’s syndrome
    4. Homocystinuria
      1. Ans(2)
  13. A feulgen reaction is a cytochemical test for:
    1. mRNA
    2. tRNA
    3. DNA
    4. All of the above
      1. Ans(3)
  14. The following are single gene disorder except:
    1. Hemochromatosis
    2. Cystic fibrosis
    3. William’s syndrome
    4. Huntington’s disease
      1. Ans(3)
  15. Multifactoral inheritance is known as:
    1. Neurofibroma
    2. Hemophilia
    3. Cardiac septal defects
    4. Hypophosphatemic defects
      1. Ans(2)
  16. Which of the following pairs is not correctly matched?
    1. Turner’s syndrome ….. 45,(XO)
    2. Down syndrome……..47, XY+21
    3. Klinefelter’s syndrome …..47, XXY
    4. Marfan’s syndrome ….47, XYY
      1. Ans(4)
  17. Which of the following is not due to defect in type II collagen?
    1. Achondrogenesis II
    2. Hypochondrogenesis
    3. Stickler’s syndrome
    4. Multiple epiphyseal dysplasias
      1. Ans(4)
  18. Hypophosphatemic Vit D Resistant Rickets is?
    1. AD
    2. AR
    3. XD
    4. XR
      1. Ans(3)
  19. The abnormal chromosomal number which is the exact multiple of 23 is:
    1. Euploidy
    2. Aneuploidy
    3. Mosaicism
    4. Trisomy
      1. Ans(1)
  20. The law “Relative frequencies of each gene allele tends to remain constant from generation to generation”, was given by?
    1. Henry signs
    2. Hardy Weinberg
    3. Doug Engelberg
    4. Johanna Frank
      1. Ans(2)
  21. RET proto-oncogene is located on which chromosome
    1. 9
    2. 10
    3. 11
    4. 12
      1. Ans(2)
  22. Which of the following is autosomal recessive inherited cancer syndrome?
    1. Ataxia telangiectasia
    2. Cowden syndrome
    3. Retinoblastoma
    4. HNPCC
      1. Ans(1)
  23. A 48 years old lady presented with hepatosplenomegaly with pancytopenia. On bone marrow examination a tissue paper crumpled appearance is seen, which is the most likely product to have accumulated?
    1. Glucocerebroside
    2. Sphingomyelin
    3. Sulfatide
    4. Ganglioside
      1. Ans(1)
  24. Downs syndrome is associated with
    1. Congenital heart disease
    2. ALL
    3. Early-onset Alzheimer’s disease
    4. CNS tumor
    5. Infection
      1. Ans(1,2,3,5)
  25. Does a frameshift mutation occur due to?
    1. Transition
    2. Transversion
    3. Insertion
    4. Point mutation
      1. Ans(3)

Take the quiz to complete the lesson. For taking the quiz please enroll as a member of this site and join our gold course

All attempts have been made to give the right answers in case anything wrong please inform us through our comments section also refer standard textbooks

Most of the questions are from previous papers of  leading universities in India

Repeat questions show the importance of those questions

 

Free WordPress Themes, Free Android Games