PG NEET Microbiology MCQs 7 – Immunity

  1. Immunity may be innate or acquired. Which of the following best describes acquired immunity?
    1. Complement cascade
    2. Increase in C-reactive protein
    3. Inflammatory response
    4. Maternal transfer of antibody
      1. Ans(4)
  2. NK cells are
    1. Activated macrophages
    2. Antibody – activated T cells
    3. Null cells activated by complement
    4. Independent of antibody
      1. Ans(4)
  3. Active immunity is not acquired by:
    1. Infection
    2. vaccination
    3. Immunoglobulin transfer
    4. sub-clinical infection
      1. Ans(3)
  4.  T-cell functions are assessed by
    1. Phagocytic index
    2. T-cell count
    3. Migration inhibition test
    4. Immunoglobulin index
      1. Ans(3)
  5. Haemophilus influenzae synthesizes immunoglobulin A(IgA)protease, which enables the bacterium to penetrate and invade the host’s respiratory epithelium. This is an example of a bacterium’s ability to evade the host:
    1.  Cellular or cell-mediated immunity (CMI) against Haemophilus influenzae
    2. Nonspecific humoral immunity
    3. Nonspecific innate immunity
    4.  Specific humoral immunity
      1. Ans(4)
  6. Interferon:
    1. Is species specific
    2. Reacts directly with virus particles to inactivate them
    3. Reacts with cells, and the affected cell then becomes resistant to a number of different viruses
    4. Constitutively produced at high levels in cells but requires an inducer for activity
      1. Anns(3)
  7. Administration of the DPT vaccine would stimulate which type of immunity?
    1. Adoptive
    2. Artificial active
    3. Artificial passive
    4. Natural active
      1. Ans(2)
  8. T – cell multiplication is stimulated by
    1. Macro line
    2. Heat
    3. Bovine serum
    4. phytohemagglutinin
      1. Ans(4)
  9. When transfer factor is given as treatment it results in:
    1. natural active immunity
    2. artificial active immunity
    3. artificial active immunity
    4. adaptive immunity
      1. Ans(4)
  10. Type of receptor present on t – cells are
    1. IgA
    2. IgG
    3. Prostaglandins
    4. CD4
      1. Ans(4)
  11. Transfer factor:
    1. Can passively transfer CMI
    2. Is inactivated by heat
    3. Is resistant to nucleases
    4. All are true
      1. Ans(4)
  12. Helper cells belong to:
    1. Macrophages
    2. T-cells
    3. B-cells
    4. Monocytes
      1. Ans(2)
  13. Not true about innate immunity:
    1. Acts as the first line of defense
    2. Complement is an example
    3. It is non-specific
    4. Not affected by genetic influences
      1. Ans(4)
  14. Lysozyme is present in the following secretions of the body except:
    1. Lacrimal secretions
    2. CSF
    3. Saliva
    4. Respiratory tract secretions
      1. Ans(3)
  15. The first barrier encountered by microorganism for common exposed sites:
    1. Lysozyme
    2. Acidic pH
    3. Skin
    4. Glycogen
      1. Ans(3)
  16. The virus-infected cell is killed by:
    1. Interferons
    2. Macrophages
    3. Neutrophils
    4. Autolysis
      1. Ans(2)
  17. False about CRP is:
    1. Beta globulin
    2. Appears in acute cases of pneumonia
    3. Produced in hepatocytes
    4. Persists as inflammation subsides
      1. Ans(4)
  18. Interleukin – & produced by which one of the following?
    1. Macrophages
    2. b-cell
    3. T cell
    4. Stromal cells
      1. Ans(4)
  19. Half life of CRP
    1. 18 hours
    2. 2 hours
    3. 12 hours
    4. 15 hours
      1. Ans(1)
  20. Group B cell Lymphocyte belongs to:
    1. CD- 19
    2. CD-69
    3. CD-59
    4. CD-68
      1. Ans(1)
  21. CRP is:
    1. α 1 globulin
    2. β 1 globulin
    3. α 2 globulin
    4. Non-specific inflammatory protein
      1. Ans(2)
  22. The difference between a natural killer and cytotoxic cells is:
    1. Interferons decreased natural killer activity
    2. NK has CD4
    3. Cytotoxic cell lyse IgG coated target cells
    4. NK contains azurophilic cytoplasmic granulocyte
      1. Ans(4)
  23. The process of increasing the ability for phagocytosis of foreign bodies called as:
    1. Crossreactivity
    2. opsonization
    3. Immune tolerance
    4. Immune surveillance
      1. Ans(2)
  24. Which of the following cells is known as large granular lymphocyte?
    1. Plasma cells
    2. NK cells
    3. T cells
    4. K cells
      1. Ans(2)
  25. Lysozyme is present in all except
    1. Lacrimal secretions
    2. CSF
    3. Saliva
    4. respiratory tract secretions
      1. Ans(2)
  26. Which leukotriene is the adhesion factor for the neutrophil on the cell surface to attach to endothelium?
    1. B4
    2. C4
    3. D4
    4. E4
      1. Ans(1)
  27. True about secondary immune response:
    1. Long latent period
    2. Usually of low titer
    3. Antibodies appear in short time
    4. Persist for long
      1. Ans(3)
  28. Phagocytic cells elaborate
    1. Prostaglandins
    2. Thromboxane
    3. Leukotrienes
    4. All of te above
      1. Ans(1)
  29. These cells are involved in innate immunity, and a person lacking these cells may have a higher than normal chance of developing malignant tumors:
    1. Cytotoxic T cell
    2. natural killer cells
    3. Helper T cells
    4. Macrophages
      1. Ans(2)
  30. Runt disease is:
    1. Graft rejection
    2. Graft versus host reaction
    3. Deficient T cell function
    4. Complement deficiency
      1. Ans(3)
  31. Innate immunity against viral cells:
    1. NK cells
    2. Cytotoxic T cells
    3. B cells
    4. Memory cells
      1. Ans(1)
  32. IL – 2 is produced by
    1. T cells
    2. b cells
    3. monocytes
    4. Neutrophils
      1. Ans(1)
  33. All are true regarding NK cells except
    1. CD16 positive
    2. CD56 positive
    3. Secrete compliment like substance
    4. None
      1. Ans(4)
  34. DiGeorge syndrome is characterized by all except
    1. Congenital thymic hypoplasia
    2. Abnormal developmental of third and fourth pouches
    3. Hypothyroidism
    4. Hypocalcemic tetany
      1. Ans(3)
  35. Regarding NK cells false statement
    1. It is activated by IL – 2
    2. Express CD3 receptor
    3. It is a variant of large lymphocyte
    4. Takes part in ADCC
      1. Ans(2)
  36. The phagocytic function is assessed by:
    1. Proliferative response to mitogen
    2. Reduction of NBT
    3. Serum immunoglobulin assay
    4. Skin test with purified protein derivative
      1. Ans(2)
  37. Which cell surface marker is required for lysis of IgG- coated target cells by natural killer cells?
    1. CD3
    2. CD16
    3. CD19
    4. CD21
      1. Ans(2)
  38. Which of the following cell is known as large granular lymphocyte?
    1. Plasma cells
    2. Nk cells
    3. K cells
    4. T cells
      1. Ans(2)
  39. Which is true?
    1. Haptens react specifically with antibodies
    2. Proantigens cause delayed hyper sensitivity when applied to skin
    3. Cryptanigens are not available during antigen-antibody reaction
    4. All are true
      1. Ans(4)
  40. Transplantation of the hosts own tissue is known as:
    1. Isograft
    2. Allograft
    3. Xenograft
    4. Autograft
      1. Ans(4)
  41. Which of the following is very difficult to induce antibody:
    1. Polysaccharide
    2. Protein
    3. Lipids
    4. Repeated infections
      1. Ans(3)
  42. Pro-inflammatory cytokines include all except
    1. Interleukin 1
    2. Interleukin 2
    3. Interleukin 6
    4. TNF -alfa
      1. Ans(2)
  43. Following is true of carbohydrate antigen except one?
    1. Poor memory
    2. Polyclonal response
    3. Highly immunogenic
    4. T cell independent response
      1. Ans(3)
  44. Chemoattractant is
    1. C5a
    2. C1
    3. C3
    4. C2
      1. Ans(1)
  45. Through which of the following a T cell-independent antigen acts?
    1. T cell
    2. B cell
    3. Macrophages
    4. CD8 T cell
      1. Ans(2)
  46. Complement C5-C9 predispose to which infection?
    1. Meningococci
    2. Pneumococcal
    3. Pseudomonas
    4. All
      1. Ans(1)
  47. All the following factor influences antibody production except:
    1. Genetic factor
    2. Age
    3. Sex
    4. Nutritional status
      1. Ans(3)
  48. Which of the following acts as a chemoattractant?
    1. C3a
    2. C3b
    3. C5a
    4. LTBa
      1. Ans(4)
  49.  A discontinuous antigen epitope:
    1. Presented by MHC molecules
    2. Produced by amino acid residues on non-adjacent polypeptide sequences
    3. A representative of only a minority of B cell epitopes
    4. Produced by a continuous linear peptide sequence
      1. Ans(2)
  50. fever is caused by:
    1. IL 3
    2. IL 6
    3. IL5
    4. IL9
      1. Ans(2)

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