PG NEET Microbiology MCQs 8 – General Microbiology

1.Germ theory was given by

  1. Louis Pasteur
  2. Antony Von Leeuwenhoek
  3. Robert Koch
  4. Joseph Lister

Ans (1)

2. In the following gram stained specimen identify the bacteria seen

Image result for neisseria gonorrhoeae gram stain

  1. Neisseria gonorrhea
  2. Staphylococcus aureus
  3. Streptococcus pyogenes
  4. Haemophilus influenzae

Ans (1)

3. Obligate anaerobes grow in

  1. absence of air
  2. absence of CO2
  3. presence of CO2
  4. presence of Co2 or O2

Ans (2)

4. Principles of asepsis in surgery were introduced by

  1. Louis Pasteur
  2. Antony Von Leeuwenhoek
  3. Robert Koch
  4. Joseph Lister

Ans (4)

5. A 15-year-old boy presented with fever and chills for 3 days. On examination, he was found to have delayed skin pinch time and dry oral mucosa. A peripheral blood smear revealed the following picture. Identify the pathogens involved

Image result for plasmodium falciparum

  1. plasmodium falciparum
  2. babesia
  3. plasmodium vivax
  4. plasmodium ovale

Ans (1)

6. There is a constant increase in the number of bacteria during

  1. decline phase
  2. lag phase
  3. stationary phase
  4. exponential phase

Ans (4)

7. Koch discovered the causative organism for tuberculosis and

  1. rabies
  2. leprosy
  3. influenza
  4. cholera

Ans (4)

8. The following are images of an intestinal nematode. Which of these are true about it

Related image

  1. filariform larvae are infective for humans as shown in the diagram
  2. transmitted usually through contaminated food and water
  3. females of these species show pathogenesis
  4. triclabendazole is the drug of choice

Ans (2)

9. Quellung reaction is associated with

  1. Q fever
  2. capsular delineation
  3. capsular degeneration
  4. bile solubility

Ans (2)

10. Which of the following is not one of the Koch’s postulates

  1. the organism is found regularly in the lesion of the diseases
  2. the organism can be isolated from diseased tissues in pure culture on artificial media
  3. inoculation of pure culture produces a similar disease in experimental animals
  4. treatment of the disease with a broad spectrum oral antimicrobial dependably eradicate the organism and cures the diseases

Ans (4)

11. A patient with benign prostatic hypertrophy was admitted in the hospital for 3 weeks. He later developed suspected catheter-associated urinary tract infection. The tip of the catheter was sent for culture on blood agar. After 24 hours the blood agar showed the following appearance. What is the likely causative agent of UTI

Image result for blood agar of proteus mirabilis

  1. Proteus mirabilis
  2. Pseudomonas
  3. Escheria coli
  4. Klebsiella pneumonia

Ans (1)

12. Which of the following are acid-fast with 20% H2SO4

  1. M avium
  2. M lepra
  3. actinomyces
  4. nocardia

Ans (1)

13. True about bacteria are all except

  1. unicellular
  2. prokaryotic
  3. DNA or RNA
  4. do not contain chlorophyll

Ans (3)

14. What Treponema is seen in the silver impregnation micrograph below

Image result for leptospira on silver impregnation

  1. Borrelia burgodorferi
  2. leptospira interrogans
  3. Treponema pallidum
  4. Ehrlichia chaffeensis

Ans (2)

15. Which of the following bacteria are acid fast

  1. actinomycetes
  2. nocardia
  3. streptomyces
  4. all the others are right

Ans (2)

16. Prokaryotes do not possess

  1. rigid cell wall
  2. flagella
  3. ribose sugar
  4. well defined nuclear membrane

Ans (4)

17. Egg with a single knob hooks polar filament. What is the correct statement

 

  1. treatment of choice is albendazole
  2. disease transmitted by uncooked pork
  3. both adult and larva stage is seen in the host
  4. transient diarrhea cured spontaneously

Ans (3)

18. Silver impregnation method of staining is done to demonstrate

  1. mycobacteria
  2. spirochaetes
  3. both are right
  4. both are wrong

Ans (2)

19. Which of the following organism does not have a cell wall

  1. mycoplasma
  2. rickettsia
  3. chlamydia
  4. spirochetes

Ans (1)

20. A 23-year-old male presented with abdominal pain and bloody diarrhea of one-week duration. The following colonoscopic biopsy is diagnostic of infection with

Image result for colonoscopic biopsy finding in amoebiasis

  1. giardiasis
  2. amoebiasis
  3. enterobiasis
  4. severe bacterial infection

Ans (2)

21. Negative staining demonstrates while positive stain does not demonstrate capsule. This is because capsule is composed of

  1. LPS
  2. polysaccharide
  3. carbohydrate
  4. fat

Ans (2)

22. Prokaryotes have

  1. well defined nucleus
  2. steroids
  3. muramic acid
  4. all of the above

Ans (3)

23. A 40 year old HIV male positive patient comes with odynophagia and watery diarrhea. An endoscopy reveals esophageal and gastric candidiasis. A wet mount of the stool of the patient reveals the following picture. What is true about this helminth.

Image result for strongyloides rhabditiform larvae

  1. filariform larvae are infective to human as shown in the diagram
  2. usually transmitted through contaminated water and food
  3. females of this species show parthogenesis
  4. drug of choice is triclabendazole

Ans (3)

24. Metachromatic granules are seen in all except

  1. Yersinia pestis
  2. mycobacteria
  3. corneybacterium
  4. staphylococcus

Ans (4)

25. The cell wall of a gram-negative organism contains

  1. lipopolysaccharide
  2. teichoic acid
  3. the other two
  4. none of the others are right

Ans (1)

26. The following pap smear shows infestation by

Image result for actinomyces pap smear

  1. trichomonas
  2. candida
  3. herpes simplex virus type 2
  4. actinomyces

Ans (4)

27. Selective inhibition of synthesis of dipicolinic acid would most likely inihibit the formation of

  1. bacterial flagella
  2. bacterial spore
  3. eukaryotic cilia
  4. eukaryotic flagella

Ans (2)

28. Amino acids are found in the protein peptide glycan and capsule of bacteria. Which of the following amino acids is found only in peptidoglycan

  1. L Lysine
  2. diaminopimelic acid
  3. D glutamate
  4. L alanine

Ans (2)

29. A 23-year-old female presents with fever and altered sensorium for two days with the following leision on the legs. her BP is 70/50 mm Hg and neck stiffness is present. Lumbar puncture reveals cloudy turbid CSF with 4200 cells/ui. Protein level 168 and glucose 21 mg/dl. Which of the following correctly describes the organism causing this condition.

Image result for purpuric rash meningococcal septicaemia

  1. gram-negative diplococci kidney shaped oxidase positive
  2. gram-negative diplococci ferment glucose and maltose
  3. gram-negative diplococci catalase negative bacitracin sensitive
  4. gram-negative diplococci lanceolate catalase negative optochin sensitive

Ans (2)

30. Which organism would most likely cause infection after a disinfection procedure that killed vegetative cells but did not kill spores

  1. Chlamydia
  2. Clostridia
  3. Eschericia
  4. Pseudomonas

Ans (2)

31. Endotoxins are

  1. heat labile
  2. polysaccharide and lipid complex
  3. strongly antigenic
  4. exhibit specific pharmacological effect for each endotoxin

Ans (2)

32. Gram stain shows most likely which organism

Image result for streptococcus pneumoniae

  1. Neisseria meningitis
  2. Staphylococcus aureus
  3. Streptococcus pyogenes
  4. Streptococcus pneumoniae

Ans (4)

33. Dipicolinic acid is found in

  1. gram positive cell wall
  2. gram negative cell wall
  3. fungus
  4. spore

Ans (4)

34. The endotoxin activity of gram-negative bacteria is present in

  1. carbohydrate
  2. protein
  3. lipid
  4. inorganic substance

Ans (3)

35. Identify the wrong statement about L forms

  1. observed by Kleinberger noble
  2. L forms are seen only in streptococcus group of organisms
  3. originally reported in streptobacillus moniliformis
  4. develop in the presence of penicillin

Ans (2)

36. The eukaryotic membrane does not contain

  1. cholesterol
  2. triglycerides
  3. lecithin
  4. carbohydrate

Ans (2)

37. Endotoxin is produced by

  1. cell wall
  2. cell membrane
  3. lysosome
  4. mitochondria

Ans (1)

38. All are features of fimbriae except

  1. also called pili
  2. seen in gram-negative bacilli
  3. hair like appendages
  4. shorter and thinner than flagella
  5. all are wrong

Ans (5)

39. Mesosomes are

  1. formed by invagination of the cell membrane
  2. more prominent in gram-positive bacteria
  3. both are true
  4. both are false

Ans (3)

40. Which of the following is a characteristic of endotoxin

  1. protein
  2. heat stable
  3. enzymatic action
  4. active in minute doses

Ans (2)

41. Sterols are present in the cytoplasmic membrane of

  1. mycoplasma
  2. bacillus
  3. corneybacterium
  4. proteus

Ans (1)

42. True about bacterial capsule is A/E

  1. prevents phagocytosis
  2. stains by gram stain
  3. protects bacteria from lytic enzymes
  4. lost by repeated by subcultures

Ans (2)

43. In CSF Limulus amoebocyte lysate assay is positive in which of the following

  1. TBM
  2. gram-negative meningitis
  3. viral meningitis
  4. chemical meningitis

Ans (2)

44. Fever leukopenia DIC and hypotension are caused by members of the Enterobacteriaceae family are most strongly associated with which structure

  1. H antigen
  2. K antigen
  3. lipid A
  4. polysaccharide

Ans (3)

45. Darting motility is found in

  1. shigella
  2. campylobacter
  3. eschericia
  4. Aeromonas

Ans (2)

46. True about O antigen of Enterobacteriaceae

  1. are susceptible to heat
  2. usually not detected by bacterial agglutination
  3. most external part of cell wall LPS
  4. is of single antigenic type

Ans (3)

47. The exotoxin is produced by

  1. staphylococcus
  2. vibrio
  3. clostridium
  4. all are right

Ans (4)

48. True about flagella A/E

  1. highly antigenic
  2. not visible by simple staining procedures
  3. in spirochetes flagellate do not protrude into extracellular environment hence called endo flagella
  4. longer than pili
  5. none are right

Ans (5)

49. Endotoxic shock is initiated by

  1. endothelial injury
  2. peripheral vasodilation
  3. increased vascular permeability
  4. cytokine action

Ans (4)

50. All are characteristics of exotoxins except

  1. heat labile
  2. neutralized by antibody
  3. secreted by gram negative and gram positive organism
  4. weakly antigenic

Ans (4)

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