PG NEET Microbiology MCQs 12 – Immunity

1.The receptors for pattern recognition on the cell surface to intracellularly is

  1. NOD proteins
  2. toll-like receptors
  3. RIG 1 proteins
  4. all the  others are right

Ans (4)

2. False statement is

  1. Ag-Ab complex activates the classical complement pathway
  2. lipopolysaccharide activates the alternate complement pathway
  3. C4 C2 complement is involved in alternative complement pathway
  4. factor B and D is involved in alternative complement pathway

Ans (3)

3. Which of the following are pan T antigen

  1. CD2,CD3,CD5,CD7
  2. CD2,CD3,CD4,CD5
  3. CD3,CD5,CD7,CD9
  4. CD2,CD4,CD6,CD8

Ans (1)

4. Which toll-like receptor is bound to flagella

  1. TLR2
  2. TLR3
  3. TLR4
  4. TLR5

Ans (4)

5. C3 convertase in alternative complement pathway is

  1. C4b2a
  2. C3b
  3. C3bBb
  4. C3a

Ans (3)

6. Markers of virgin T cells and memory T cells

  1. CD45RB/CD45RR
  2. CD45RA/CD45RB
  3. CD45RA/CD45RO
  4. CD45RO/CD45RA

Ans (3)

7. False about passive immunity

  1. acquired within days
  2. memory is absent
  3. exquisite specificity
  4. induced by infection and immunogen

Ans (4)

8. B lymphocyte is found in

  1. spleen follicle
  2. lymph node paracortex
  3. lymphoid sheaths
  4. none

Ans (1)

9. Not a source of macrophages

  1. enzymes like proteases, lysozyme and elastase
  2. cytokine IL1,6,8,12 and TNF αand β
  3. colony stimulating factor and angiotensin converting enzyme
  4. complements C1-C3

Ans (4)

10. Injection of transfer factor gives

  1. active immunity
  2. passive immunity
  3. adoptive immunity
  4. none are right

Ans (3)

11. Neonatal thymectomy leads to

  1. decrease size of the germinal center of the lymph node
  2. decrease size of the paracortical area of the lymph node
  3. increased bone marrow production
  4. increased antibody production of B cell

Ans (2)

12. Not a non-professional antigen presenting cell

  1. pancreatic beta cell
  2. dendritic cell
  3. glial cell
  4. vascular endothelial cell
  5. fibroblast

Ans (2)

13. T cell-dependent antigen all are right except

  1. all classes of antibodies are activated
  2. they have immunological memory
  3. metabolization is slow
  4. all are true

Ans (4)

14. Hofbauer cell are seen in

  1. brain
  2. heart
  3. lung
  4. placenta

Ans (4)

15. MHC class III gene does not encode

  1. TNF α and β/heat shock proteins
  2. steroid 21 hydroxylase
  3. complement component C3
  4. C3 convertase

Ans (3)

16. Superantigen causes

  1. enhancement of phagocytosis
  2. antigen presentation by macrophages
  3. polyclonal activation of B cell
  4. activation of complement

Ans (3)

17. The most potent stimulator of naive T cell is

  1. mature dendritic cell
  2. follicular dendritic cell
  3. B lymphocyte
  4. monocyte

Ans (1)

18. HLA compatibility is tested by

  1. microcytotoxicity test
  2. restriction fragment length polymorphism
  3. tissue matching
  4. all the above

Ans (4)

19. Idiotype is

  1. changes in the variable region of an immunoglobulin
  2. genetic variation in the constant region of an immunoglobulin
  3. multiple alleles that exist for some genes
  4. the smallest unit of antigenicity

Ans (1)

20. An adaptive immune response that remains unresponsive to nude mice is

  1. antibody formation
  2. cell-mediated immune response
  3. the killing of the virus-infected or malignant cell
  4. graft rejection
  5. all are right

Ans (5)

21. Which pair is correct

  1. alpha interferon – leucocyte
  2. beta interferon – fibroblast
  3. gamma or immune interferon – T lymphocyte
  4. all are right

Ans (4)

22. Enzymatic digestion of antibody with  metacarpoethanal generates

  1. 1 Fab fragments
  2. one Fc fragment and many small fragments
  3. 2 H and 2 L chains
  4. 2 H chains alone

Ans (3)

23. False statement about T cell receptor is

  1. in 95% of T cell, the TCR contains disulfide link heterodimer made of α and β polypeptide chain
  2. the αβ TCR recognizes peptide antigen that is presented by major histocompatible complex molecules on the surface of antigen presenting cells
  3. γδTCR recognizes peptide antigens that are presented by major histocompatible complex molecules
  4. γδT cells forms aggregates on the skin and GIT mucosal lining to show that they are the barriers preventing the entry of microbes into the body

Ans (3)

24. Clonal selection implies

  1. brother and sister have a similar immune response
  2. only certain cells can produce an immune response
  3. antigens increase mitosis in specific lymphocyte
  4. B cells have multiple types of antigen receptors

Ans (3)

25. False about immunoglobulin is

  1. Presence of IgM indicates recent infection
  2. IgD is a surface immunoglobulin on B cells
  3. IgE causes type I hypersensitivity
  4. IgG is the only immunoglobulin to cross the maternal placenta
  5. Presence of IgG can be used to detect fetal infection

Ans (5)

26. MHC class I antigen is located in all the following except

  1. RBC
  2. platelet
  3. T lymphocyte
  4. B lymphocyte

Ans (1)

27. Which route of administration of a shocking dose of drug causes sever anaphylaxis

  1. intradermal
  2. subcutaneous
  3. oral
  4. intravenous

Ans (4)

28. Secretory component of IgA is formed by

  1. two monomer unit joined together by a glycopeptide chain
  2. plasma cell only
  3. lining mucosal cell only
  4. none

Ans (1)

29. False statement about MHC class II antigen is

  1. prsents antigen via endogenic pathway
  2. β2 binds to CD4 on helper T cell
  3. present on all nucleated cell and platelet
  4. peptide binds to α1/β1 groove

Ans (3)

30. Shultz Dale phenomenon is

  1. Type I hypersensitivity reaction
  2. Type II hypersensitivity reaction
  3. Type III hypersensitivity reaction
  4. Type IV hypersensitivity reaction

Ans (1)

31. Which is a surface immunoglobulin of B cell

  1. IgA
  2. IgG
  3. IgM
  4. IgD

Ans (3)

32. HLA complex of genes is located on

  1. chromosome 5
  2. chromosome 6
  3. chromosome 7
  4. chromosome 8

Ans (2)

33. Which is not a type I hypersensitive reaction

  1. atopy
  2. arthus reaction
  3. anaphylaxis
  4. PK reaction

Ans (2)

34. The lowest concentration of IgG immunoglobulin

  1. IgG1
  2. IgG2
  3. IgG3
  4. IgG4

Ans (4)

35. Interleukin that cause maturation of eosinophil

  1. IL2
  2. IL3
  3. IL4
  4. IL5

Ans (4)

36. Spring Cataarh is what type hypersensitivity reaction

  1. Type I hypersensitivity reaction
  2. Type II hypersensitivity reaction
  3. Type III hypersensitivity reaction
  4. Type IV hypersensitivity reaction

Ans (1)

37. ——————- is responsible for agglutination and ———– id responsible for precipitation

  1. IgA/IgG
  2. IgM/IgG
  3. IgE/IgG
  4. IgG/IgM

Ans (2)

38. T and B cell proliferation is inhibited by

  1. TGF β
  2. IFNα
  3. IL1
  4. IL2

Ans (1)

39. Not a cell mediated hypersensitive reaction

  1. tuberculin test
  2. frei test
  3. casonis test
  4. none of the others

Ans (3)

40. In precipitation reaction excess of antibody is seen in

  1. pro zone phenomenon
  2. zone of equivalence
  3. post zone phenomenon
  4. none

Ans (3)

41. False about transfer factor

  1. it is a low molecular weight substance which is easily dialysable
  2. it is localized to the injection site
  3. is used in Wiskoot Aldrich syndrome
  4. used in the treatment of SLE malignant melanoma and lepromatous leprosy

Ans (2)

42. Two days after administration of a drug antibody developed and produced hemolysis what reaction is that

  1. Type I hypersensitivity reaction
  2. Type II hypersensitivity reaction
  3. Type III hypersensitivity reaction
  4. Type IV hypersensitivity reaction

Ans (2)

43. Ouchtherlony procedure is

  1. double diffusion in one dimension
  2. double diffusion in two dimension
  3. single diffusion in one dimension
  4. single diffusion in two dimension

Ans (2)

44. Cell-mediated immunity is due to

  1. activation of phagocytes
  2. mediated by helper T cell, suppressive T cell and cytotoxic T cell
  3. the release of various cytokines
  4. all the above

Ans (4)

45. Erythema wheal and flare is seen in

  1. Type I hypersensitivity reaction
  2. Type II hypersensitivity reaction
  3. Type III hypersensitivity reaction
  4. Type IV hypersensitivity reaction

Ans (1)

46. Naeglers or lecithinase test is an example of

  1. precipitation
  2. agglutination
  3. neutralization
  4. opsonization

Ans (3)

47. Not a function of CD4 helper cell

  1. immunogenic memory
  2. produce immunoglobulins
  3. activates macrophages
  4. activates cytotoxic cells

Ans (2)

48. Eichwald Shulmser effect is

  1. male to female transplant is rejected
  2. female to male transplant is rejected
  3. male to male transplant is rejected
  4. female to female transplant is rejected

Ans (1)

49. Wasserman’s  reaction is an example of

  1. precipitation
  2. agglutination
  3. neutralization
  4. complement fixation

Ans (4)

50. Hereditary angioneurotic edema occurs due to deficiency of which complement

  1. C1C2C3
  2. C5-C8
  3. C1 inhibitor
  4. C9

Ans (3)

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