NEET PG Medicine MCQs 124 – Connective Tissue Disorders- 7

1. All of the following are small vessel vasculitis, except:

  1. Wegner’s granulomatosis
  2. Microscopic polyangiitis
  3. Polyarteritis Nodosa
  4. Henoch-Schonelin purpura


2. Which of the following is a ‘Small Vessel Vasculitis’:

  1. Polyarteritis Nodosa (PAN)
  2. Microscopic polyangiitis
  3. Giant cell vasculitis
  4. Takayasu’s Disease


3. All of the following are small vessels vasculitis, except:

  1. Classical PAN
  2. Wegner’s granulomatosis
  3. HSP
  4. Churg Strauss Syndrome
  5. Microscopic Polyangiitis


4. Which of the following are Small Vessel Vacuitides (Select two best options)

  1. HUS
  2. HSP
  3. Kawasaki disease
  4. Churg-Strauss Syndrome


5. ANCA is found in all of the following except:

  1. Wegner’s granulomatosis
  2. Churg-Strauss disease
  3. Microscopic polyangiitis
  4. Takayasu arteritis
  5. SLE


6. c-ANCA is characteristic for:

  1. polyarteritis nodosa
  2. P.G.N.
  3. Henoch’s Schonlein Purpura
  4. Wegener’s granulomatosis


7. C-ANCA is associated with:

  1. Wegener’s Granulomatosis
  2. Microscopic Polyangiitis
  3. Churg-Strauss Syndrome
  4. Polyarteritis Nodasa (PAN)


8. C-ANCA positivity indicates, antibody formed against:

  1. Proteinase 3
  2. Myeloperoxidase
  3. Cytoplasmic antinuclear antibody
  4. Anticentromere antibody


9. P-ANCA is characteristic for:

  1. PAN
  2. Microscopic polyangiitis
  3. Wegener’s granulomatosis
  4. Henoch-Schonlein purpura


10. The presence of anti-saccharomyces cerevisiae antibody is a surrogate marker of one of the following:

  1. Celiac disease
  2. Crohn’s disease
  3. Ulcerative colitis
  4. Tropical sprue


11. Antiendomysial Antibody is typically seen in:

  1. Celiac Disease
  2. SLE
  3. Tropical sprue
  4. Collagenous Colitis


12. All of the following condition is associated with granulomatous pathology, except:

  1. Wegner’s Granulomatosis (WG)
  2. Takayasu Arteritis (TA)
  3. Polyarteritis Nodosa (Classic PAN)
  4. Giant Cell Arteritis (GCA)


13. A person with the involvement of the upper respiratory tract, lungs, and kidney shows evidence of granulomas on histopathology. The most likely diagnosis is:

  1. Wegener’s Granulomatosis
  2. Goodpasture Syndrome
  3. Tuberculosis
  4. Sarcoidosis


14. A 20-year-old woman presents with bilateral conductive deafness, palpable purpura on the legs and hemoptysis. Radiograph of the chest shows a thin-walled cavity in the left lower zone, investigations reveal total leukocyte count 12000/mm3, red cell casts in the urine and serum creatinine 3mg/dL. What is the most probable diagnosis?

  1. Henoch-Schonlein purpura
  2. Polyarteritis nodosa
  3. Wegener’s granulomatosis
  4. Disseminated tuberculosis


15. A 25 years old female develops serous otitis media of left ear with a cough and occasional hemoptysis and hematuria and epistaxis for one and half months her. Hemoglobin is 7 gm B.P. > 170/100, proteinuria +++, RA positive (+ve) and ANCA positive (+ve), the likely cause is-

  1. Wegener’s granulomatosis
  2. Rheumatoid arthritis
  3. Rapidly proliferative glomerulonephritis
  4. Good Pasteur’s syndrome


16. A 25 years old female develops serous otitis media of left ear with a cough and occasional hemoptysis and hematuria and epistaxis for one and half months her hemoglobin is 7 gm. B.P. is > 170/100, proteinuria +++, RA –ve and ANCA –ve, the likely cause is-

  1. Wegener’s granulomatosis
  2. Rheumatoid arthritis
  3. Rapidly proliferative glomerulonephritis
  4. Goodpasture’s syndrome


17. Wegener’s granulomatosis does not affect:

  1. Kidney
  2. Lungs
  3. Eye
  4. Liver


18. Cavitating lesion in the lung is seen in:

  1. PAN
  2. SLE
  3. Wegner’s granulomatosis
  4. Sjogren’s syndrome


19. In polyarteritis nodosa, aneurysms are seen in all, except:

  1. Kidney
  2. Lung
  3. Liver
  4. Pancreas


20. A 30 years old male patient presents with complaints of weakness in the right upper and both lower limbs of the last 4 months. He developed digital infarcts involving 2nd and 3rd fingers on the right side and 5th finger on the left side. On examination, BP was 160/140 mm Hg, all peripheral pulses were palpable and there was asymmetrical neuropathy. Investigations showed a Hb 12 gm, TLC-12000 Cu mm, Platelets 4,30,000, ESR-49 mm. urine examination showed proteinuria and RBC – 10-15/hpf with no casts. Which of the following is the most likely diagnosis?

  1. Polyarteritis nodosa
  2. Systemic lupus erythematosus
  3. Wegener’s granulomatosis
  4. Microscopic polyangiitis


21. All of the following statements about Churg Strauss Syndrome are true, except:

  1. Marked Eosinophilia
  2. Mononeuritis multiplex is common
  3. Renal failure is common
  4. Often associated with Allergic Rhinitis


22. Which of the following is more frequently seen in Churg Strauss Syndrome in comparison to Wegener’s Granulomatosis:

  1. Renal involvement
  2. Lower Respiratory Tract involvement
  3. Eye involvement
  4. Upper Respiratory Tract involvement


23. A feature of microscopic polyangiitis is:

  1. IgG deposits in the kidney
  2. Bronchospasm
  3. Renal involvement in 80% of cases
  4. All of the above


24. All of the following features may be used to distinguish PAN from microscopic Polyangiitis, except:

  1. ANCA positivity
  2. RBC cast in urine
  3. Necrotizing vasculitis
  4. HBV infection


25. All of the following are true about Temporal Arteritis except:

  1. Polymyalgia Rheumatica
  2. Anemia
  3. Low ESR
  4. Sudden blindness


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