NEET PG Medicine MCQs 127 – Connective Tissue Disorders- 10

1. Anti-double stranded DNA is highly specific for:

  1. Systemic sclerosis
  2. L.E.
  3. Polymyositis
  4. Rheumatic sclerosis


2. Anti ds DNA is most specific for:

  1. SLE
  2. Rheumatoid arthritis
  3. Scleroderma
  4. Polymyositis


3. Most specific Antibodies for SLE are:

  1. Anti-Ro
  2. Anti-Jo
  3. Anti-Sm
  4. Anti-ds DNA
  5. Anti-La


4. Which of the following antibodies is highly specific for systemic lupus erythematosus?

  1. Anti – Sm
  2. Anti – RO-I
  3. Anti 0 UIRNP
  4. Anti – Centromere


5. Demonstration of which antibody is specific for a diagnosis of SLE?

  1. Single-stranded DNA
  2. Double –standed DNA
  3. Centromere
  4. RNA


6. Best marker for drug induced lupus is:

  1. Antihistone antibodies
  2. Anti ds DNA
  3. ANA
  4. Anti smith Ab


7. Drug induced Lupus can be identified by:

  1. Anti-histone abtibodies
  2. Double stranded DNA antibodies
  3. Antinuclear antibodies
  4. Anti-SM antibodies


8. Which of the following is the diagnostic of mixed connective tissue disease?

  1. Antinuclear antibody
  2. SCL-70 antibody
  3. UI-RNP antibody
  4. Anti-CCP antibody


9. Anticentromere antibodies are most commonly associated with:

  1. Diffuse cutaneous systemic sclerosis
  2. Mixed connective tissue disease
  3. CREST syndrome
  4. Polymyositis


10. Which of the following parameters are included in the Revised (ACR) Criteria for SLE:

  1. ANA
  2. Anti DS-DNA Antibody
  3. Lymphopenia<10000/microL
  4. Proteinuria >7500mg/d
  5. Leucocytopenia<1000/microL


11. According to current guidelines which of the following is not a clinical manifestation used to diagnose systemic lupus erythematosus?

  1. Leucopenia
  2. Malar rash
  3. Raynaud phenomenon
  4. Photosensitivity


12. The characteristic feature of SLE is:

  1. Uveitis
  2. Joint deformity
  3. Polyserositis
  4. Cavitating lesion in the lung


13. A 23-year old woman has experienced episodes of myalgias, pleural effusion, pericarditis, and arthralgias without joint deformity over course of several years. The best laboratory screening test to diagnose her disease would be:

  1. CD4 lymphocyte count
  2. Erythrocyte sedimentation rate
  3. Antinuclear antibody
  4. Assay for thyroid hormones


14. The most specific antibody for SLE is?

  1. Anti Sm antibodies
  2. Anti-ds DNA antibodies
  3. Anti-Histone antibodies
  4. Anti Ro (SS-A) antibodies


15. Erosive arthritis is seen in all except:

  1. SLE
  2. Gout
  3. Osteoarthritis
  4. Old age


16. Joint erosions are not a feature of:

  1. Rheumatoid arthritis
  2. Psoriasis
  3. Multicentric reticulohistiocytosis
  4. Systemic lupus erythematosus


17. In which of the following arthritis erosions are not seen:

  1. Rheumatoid arthritis
  2. Systemic lupus erythematosus (SLE)
  3. Psoriasis
  4. Gout


18. Features of SLE include all of the following except:

  1. Recurrent abortion
  2. Sterility
  3. Coomb’s positive hemolytic anemia
  4. Psychosis


19. All of the following are true about SLE except:

  1. Autoimmune Hematolytic Anemia
  2. (upward arrow)ed ANA
  3. Anti-ds DNA
  4. Raynaud’s phenomenon
  5. Joint deformity


20. Shrinking Lung Syndrome is seen in:

  1. SLE
  2. Rheumatoid Arthritis
  3. Scleroderma
  4. Sarcoidosis


21. Shrinking lung is a feature of:

  1. SLE
  2. Rheumatoid arthritis
  3. Scleroderma
  4. Sarcoidosis


22. Onion skin spleen is seen in:

  1. ITP
  2. Thalassemia
  3. SLE
  4. scleroderma


23. Deposition of Anti-ds DNA Ab in kidney, skin choroid plexus and joints is seen in:

  1. SLE
  2. Glad pasture
  3. Scleroderma
  4. Raynaud’s disease


24. Autoimmune destruction of platelet is seen in:

  1. SLE
  2. Rheumatoid arthritis
  3. Reiter disease
  4. Polyarteritis nodosa


25. All of the following are true about Drug-Induced Lupus in comparison to Idiopathic SLE, except:

  1. More common in Females
  2. Milder Disease
  3. Presence of Renal or CNS Disease is rate
  4. Hypocomplementemia is less common


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