NEET PG Medicine MCQs 127 – Connective Tissue Disorders- 10

1. Anti-double stranded DNA is highly specific for:

  1. Systemic sclerosis
  2. L.E.
  3. Polymyositis
  4. Rheumatic sclerosis

Ans(2)


2. Anti ds DNA is most specific for:

  1. SLE
  2. Rheumatoid arthritis
  3. Scleroderma
  4. Polymyositis

Ans(1)


3. Most specific Antibodies for SLE are:

  1. Anti-Ro
  2. Anti-Jo
  3. Anti-Sm
  4. Anti-ds DNA
  5. Anti-La

Ans(3)


4. Which of the following antibodies is highly specific for systemic lupus erythematosus?

  1. Anti – Sm
  2. Anti – RO-I
  3. Anti 0 UIRNP
  4. Anti – Centromere

Ans(1)


5. Demonstration of which antibody is specific for a diagnosis of SLE?

  1. Single-stranded DNA
  2. Double –standed DNA
  3. Centromere
  4. RNA

Ans(2)


6. Best marker for drug-induced lupus is:

  1. Antihistone antibodies
  2. Anti-ds DNA
  3. ANA
  4. Anti Smith Ab

Ans(1)


7. Drug-induced Lupus can be identified by:

  1. Anti-histone antibodies
  2. Double-stranded DNA antibodies
  3. Antinuclear antibodies
  4. Anti-SM antibodies

Ans(1)


8. Which of the following is the diagnostic of mixed connective tissue disease?

  1. Antinuclear antibody
  2. SCL-70 antibody
  3. UI-RNP antibody
  4. Anti-CCP antibody

Ans(3)


9. Anticentromere antibodies are most commonly associated with:

  1. Diffuse cutaneous systemic sclerosis
  2. Mixed connective tissue disease
  3. CREST syndrome
  4. Polymyositis

Ans(3)


10. Which of the following parameters are included in the Revised (ACR) Criteria for SLE:

  1. ANA
  2. Anti DS-DNA Antibody
  3. Lymphopenia<10000/microL
  4. Proteinuria >7500mg/d
  5. Leucocytopenia<1000/microL

Ans(1,2)


11. According to current guidelines which of the following is not a clinical manifestation used to diagnose systemic lupus erythematosus?

  1. Leucopenia
  2. Malar rash
  3. Raynaud phenomenon
  4. Photosensitivity

Ans(3)


12. The characteristic feature of SLE is:

  1. Uveitis
  2. Joint deformity
  3. Polyserositis
  4. Cavitating lesion in the lung

Ans(3)


13. A 23-year old woman has experienced episodes of myalgias, pleural effusion, pericarditis, and arthralgias without joint deformity over course of several years. The best laboratory screening test to diagnose her disease would be:

  1. CD4 lymphocyte count
  2. Erythrocyte sedimentation rate
  3. Antinuclear antibody
  4. Assay for thyroid hormones

Ans(3)


14. The most specific antibody for SLE is?

  1. Anti Sm antibodies
  2. Anti-ds DNA antibodies
  3. Anti-Histone antibodies
  4. Anti Ro (SS-A) antibodies

Ans(1)


15. Erosive arthritis is seen in all except:

  1. SLE
  2. Gout
  3. Osteoarthritis
  4. Old age

Ans(1)


16. Joint erosions are not a feature of:

  1. Rheumatoid arthritis
  2. Psoriasis
  3. Multicentric reticulohistiocytosis
  4. Systemic lupus erythematosus

Ans(4)


17. In which of the following arthritis erosions are not seen:

  1. Rheumatoid arthritis
  2. Systemic lupus erythematosus (SLE)
  3. Psoriasis
  4. Gout

Ans(2)


18. Features of SLE include all of the following except:

  1. Recurrent abortion
  2. Sterility
  3. Coomb’s positive hemolytic anemia
  4. Psychosis

Ans(2)


19. All of the following are true about SLE except:

  1. Autoimmune Hematolytic Anemia
  2. (upward arrow)ed ANA
  3. Anti-ds DNA
  4. Raynaud’s phenomenon
  5. Joint deformity

Ans(5)


20. Shrinking Lung Syndrome is seen in:

  1. SLE
  2. Rheumatoid Arthritis
  3. Scleroderma
  4. Sarcoidosis

Ans(1)


21. Shrinking lung is a feature of:

  1. SLE
  2. Rheumatoid arthritis
  3. Scleroderma
  4. Sarcoidosis

Ans(1)


22. Onion skin spleen is seen in:

  1. ITP
  2. Thalassemia
  3. SLE
  4. scleroderma

Ans(3)


23. Deposition of Anti-ds DNA Ab in kidney, skin choroid plexus and joints is seen in:

  1. SLE
  2. Glad pasture
  3. Scleroderma
  4. Raynaud’s disease

Ans(1)


24. Autoimmune destruction of platelet is seen in:

  1. SLE
  2. Rheumatoid arthritis
  3. Reiter disease
  4. Polyarteritis nodosa

Ans(1)


25. All of the following are true about Drug-Induced Lupus in comparison to Idiopathic SLE, except:

  1. More common in Females
  2. Milder Disease
  3. Presence of Renal or CNS Disease is a rate
  4. Hypocomplementemia is less common

Ans(1)


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