NEET PG Medicine MCQs 128 – Hematology – 1

 

1. All are true for sickle cell anemia, except:

  1. Pulmonary arterial hypertension
  2. Fish vertebra
  3. Leucopenia
  4. Increased size of the heart

Ans(3)


2. All of the following statements are true about sickle cell disease except:

  1. The patient may require a frequent blood transfusion
  2. Acute infection is the most common cause of mortality before 3 years of age
  3. There is a positive correlation between conc. HBS and polymerization of HBS
  4. Patient presents early in life before 6 months of age

Ans(4)


3. All of the following are true about sickle cell disease, except:

  1. Mutation in chain
  2. Symptoms ameliorated by HbF
  3. Venoocclusive cries are the cause of morbidity
  4. Bone pain is presenting feature

Ans(1)


4. Commonest acute presentation of sickle cell anemia is:

  1. Priapism
  2. Bone pain
  3. Fever
  4. Splenomegaly

Ans(2)


5. Heterozygous sickle cell anemia gives protection against:

  1. G6PD
  2. Malaria
  3. Thalassemia
  4. Dengue fever

Ans(2)


6. Which of the following is not seen on hemoglobin electrophoresis in sickle cell anemia:

  1. HbA
  2. HbA2
  3. HbF
  4. HbS

Ans(1)


7. Sickle cell trait patient does not have manifestations as that of Sickle cell disease, because:

  1. 50% HbS is required for the occurrence of sickling
  2. HbA prevents sickling
  3. HbS is less than 50% & HbA has low affinity for HbS
  4. HbA prevents polymerization of Hbs

Ans(3)


8. The mother has sickle cell disease; Father is normal; Chances of children having sickle cell disease and sickle cell trait respectively are:

  1. 0 and 100%
  2. 25 and 25%
  3. 50 and 50%
  4. 10 and 50%

Ans(1)


9. Gamma bodies are seen in:

  1. G6- PD deficiency
  2. Hodgkin’s lymphoma
  3. Hereditary spherocytosis
  4. Sickle cell anemia

Ans(4)


10. Sickle cell anemia leads to resistance towards

  1. Falciparum
  2. Ovale
  3. Malaria
  4. Vivax

Ans(1)


11. Which of the following is a Quantitative defect in globin synthesis:

  1. Thalassemia
  2. Sickle Cell Hemoglobinopathy
  3. G6PD Deficiency
  4. Diamond- Blackfan Syndrome

Ans(1)


12. In Beta thalassemia, there is:

  1. Increase in the beta chain, decrease in alpha chain
  2. The decrease in the beta chain, increase in alpha chain
  3. The decrease in the beta chain, a decrease in alpha chain
  4. Increase in the beta chain, increase in alpha chain

Ans(2)


13. The most common mutations in Beta-thalassemia involves:

  1. Intron-1
  2. Intron-22
  3. 619 bp deletion
  4. 7 bp deletion

Ans(1)


14. What is the most common type of mutation causing alpha thalassemia?

  1. Gene duplication
  2. Large deletion
  3. Point mutation
  4. Trinucleotide repeat expansion

Ans(2)


15. A 25-year female presented with milk pallor and moderate hepatosplenomegaly. Her hemoglobin was 92d/L and fetal hemoglobin level was 65%. She has not received any blood transfusion till date. She is most likely to be suffering from:

  1. Thalassemia major
  2. Thalassemia intermedia
  3. Hereditary persistent fetal hemoglobin, homozygous state
  4. Hemoglobin D, homozygous state

Ans(2)


16. A 21-year-old male presents to the emergency department with severe anemia and hemoglobin levels of 5 gm/dl. He gives a history of similar presentation in the past which wave adequately managed by a single blood transfusion. He has not required any further blood transfusions till date. Most probable diagnosis is:

  1. Thalassemia Major
  2. Thalassemia Minor
  3. Thalassemia Intermedia
  4. Autoimmune hemolytic anemia

Ans(3)


17. A 23-year-old asymptomatic female pilot has MCV-70, ferritin – 100 g/L, Hb-10gm%, what is the cause:

  1. Thalassemia trait
  2. B12 def
  3. Folate def
  4. Iron def

Ans(1)


18. All of the following are true about thalassemia trait, Except:

  1. Microcytic hypochromic picture
  2. ed HbA2
  3. ed HbF
  4. ed HbF
  5. The patient required a blood transfusion

Ans(4)


19. All are true about thalassemia trait Except:

  1. HbF
  2. HbA2
  3. Microcytosis
  4. Severe anemia

Ans(4)


20. The most important diagnostic feature for beta thalassemia trait:

  1. Raised HbF
  2. Reduced MCH
  3. Reduced MCV
  4. Raised HbA2

Ans(4)


21. Gold Standard test for evaluation of beta thalassemia trait is:

  1. HbF
  2. HbA
  3. HbA2
  4. HbH

Ans(3)


22. True about –thalassemia trait:

  1. Increased HbF
  2. Increased HbA2
  3. Microcytosis
  4. Severe anemia

Ans(3)


23. A 32-year old female, asymptomatic, not requiring a blood transfusion, presents with Hb 13.0 gm/dl. Her HbF levels are 95%, Hb A2 1.5%, which of the following is the most likely diagnosis:

  1. Hereditary persistence of fetal hemoglobin
  2. Beta homozygous thalassemia
  3. Thalassemia intermedia
  4. Beta heterozygous thalassemia

Ans(1)


24. A child aged 2 year presents with nonspecific symptoms suggestive of anemia. On peripheral blood smear, target cells are seen. He has hypochromic microcytic picture and Hb of 6 gm. He also has ‘a positive family history’ Next investigation of choice is:

  1. Hb electrophoresis
  2. Coombs test
  3. Liver function tests
  4. Osmotic fragility test

Ans(1)


25. The peripheral blood smear of a patient shows features of thalassemia, also presented with anemia. Family history is also +ve. The investigation done to establish the diagnosis is:

  1. ESR estimation
  2. Blood spherocyte estimation
  3. Bone marrow aspiration
  4. Hb-electrophoresis

Ans(4)


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