NEET PG Medicine MCQs 129 – Hematology – 2

 

1. Diagnosis of beta Thalassemia is established by:

  1. NESTROFT Test
  2. Hb, A1 C estimation
  3. Hb electrophoresis
  4. Target cells in the peripheral smear

Ans(3)


2. NESTROFT test is used for screening of:

  1. Thalassemia
  2. Autoimmune Haemolytic Anaemia
  3. Hereditary Spherocytosis
  4. G6PD Deficiency

Ans(1)


3. The Electrophoresis Pattern in the picture best represents?

  1. Beta Thalassemia Major
  2. Beta Thalassemia Minor
  3. Alpha Thalassemia Major
  4. Alpha Thalassemia Minor

Ans(1)


4. A 5-year old girl came with a history of progressively increasing pallor since birth and hepatosplenomegaly. Which of the following is the most relevant test for achieving diagnosis:

  1. Hb electrophoresis
  2. Peripheral smear examination
  3. Osmotic fragility test
  4. Bone marrow examination

Ans(1)


5. The hair on end appearance is seen in X-rays skull in:

  1. Thalassemia
  2. Hydrocephalus
  3. Chronic malaria
  4. Sickle cell anuria

Ans(1)


6. Deletion of one alpha globing gene on one chromosome is best defined as:

  1. Hb Barts hydrops details
  2. Alpha thalassemia major
  3. Alpha thalassemia trait
  4. Alpha Thalassemia silent carrier

Ans(4)


7. Which of the following is caused by deletion of all four alpha globin genes:

  1. Beta thalassemia major
  2. Hb Barts
  3. HbH
  4.  thalassemia trait

Ans(2)


8. HbH is characterized by:

  1. Deletion of three alpha genes
  2. Deletion of three alpha and one beta gene
  3. Deletion of two alpha and two beta genes
  4. Deletion of four alpha genes

Ans(1)


9. Which of the following represent Fetal Haemoglobin (HBF)

  1. Alpha 2 Beta 2
  2. Alpha 2 Gamma 2
  3. Alpha 2 delta 2
  4. Delta 4

Ans(2)


10. Hemoglobin Portland is best defined as:

  1. Alpha 2; Delta 2
  2. Alpha 2; Epsilon 2
  3. Zeta 2; Gamma 2
  4. Zeta 2; Epsilon 2

Ans(3)


11. Haemoglobin F is raised in:

  1. Juvenile chronic myeloid leukemia
  2. Hereditary spherocytosis
  3. Congenital red cell aplasia
  4. Myasthenia gravis

Ans(1)


12. Increased levels of HBA2 on Electrophoresis may be seen in all of the following except:

  1. Beta thalassemia
  2. Alpha thalassemia
  3. Megaloblastic Anemia
  4. Hyperthyroidism

Ans(2)


13. Which of the following is NOT used for iron chelation in thalassemia patients?

  1. Kelfer
  2. Desferal
  3. Deferiprone
  4. Penicillamine

Ans(4)


14. Warm autoimmune hemolytic anemia may be seen in all of the following conditions except:

  1. Systemic lupus erythematosus
  2. – Methyldopa therapy
  3. Non-Hodgkin’s lymphoma
  4. Mycoplasma pneumonia

Ans(4)


15. Cold haemagglutinin is associated with-

  1. Anti IgM
  2. Anti IgG
  3. Anti IgA
  4. Donath Landsteiner antibody

Ans(1)


16. Autoimmune hemolytic anemia is seen in:

  1. Sickle cell anemia
  2. Chronic lymphocytic leukemia (CLL)
  3. Acute myelocytic leukemia (AML)
  4. Multiple myelomas

Ans(2)


17. Autoimmune hemolytic anemia is associated with malignancy of which lineage:

  1. T cell
  2. B cell
  3. Pre B cell
  4. Pre T cell

Ans(2)


18. Autoimmune hemolytic anemia is seen in:

  1. ALL
  2. AML
  3. CLL
  4. CML

Ans(3)


19. Coomb’s +ve Hemolytic Anaemia is seen in except:

  1. Alcoholic cirrhosis
  2. Chronic active hepatitis
  3. Primary biliary cirrhosis
  4. Primary sclerosing cholangitis

Ans(1)


20. Coombs positive hemolytic anemia associated with:

  1. TTP
  2. PAN
  3. SLE
  4. HUS

Ans(3)


21. All of the following conditions are associated with Coombs-positive hemolytic anemia except:

  1. Thrombotic thrombocytopenic purpura (TTP)
  2. Scleroderma
  3. SLE
  4. PAN

Ans(1)


22. 20 years old female presenting with anemia, mild jaundice for 2 years, peripheral smear showing spherocytes, the best investigation to be done is:

  1. Reticulocyte count
  2. Osmotic fragility test
  3. Coombs test
  4. Bone marrow aspiration

Ans(3)


23. Which of the following is an immune response cause of anaemia?

  1. Diamond Blackfan anemia
  2. Hereditary spherocytosis
  3. Glucose – 6 – phosphate dehydrogenase deficiency
  4. Hemolytic disease of the newborn

Ans(4)


24. A positive direct antiglobulin (Coombs)test indicates:

  1. Congenital red cell aplasia
  2. Hereditary spherocytosis
  3. Hemolytic disease of the newborn
  4. G6PD deficiency

Ans(3)


25. Anemia due to antibodies against blood group antigens:

  1. Hereditary spherocytosis
  2. G6PD deficiency
  3. Hemolytic disease of the newborn
  4. Alpha thalassemia major

Ans(3)


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